GHRH est un gène codé par le symbole GHRH. Communément appelé aussi: Somatoliberin; Growth hormone-releasing factor; GRF; Growth hormone-releasing hormone; Somatocrinin; Somatorelin; GHRF. GHRH a une masse de 12.45kDa et une longueur d'acide aminé de 108.
Nous proposons 1 GHRH protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
Résumé Entrez
This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Similitudes de séquence
Belongs to the glucagon family.
Localisation cellulaire
Secreted.
Utilisation biotechnologique
Can be used for targeted secretion inhibition. A construct with this protein's ligand domain inserted between the C.botulinum neurotoxin type D (BoNT/D, botD) light chain and translocation domains, when injected into rats, leads to decreased growth hormone production. The GHRH ligand domain binds to the GHRH receptor on somatotrophs where it is taken up into endosomes. There the translocation domain inserts into the membrane, releasing the light chain which cleaves synaptobrevin and inhibits growth hormone exocytosis (PubMed:24029240, PubMed:26324071).
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