GLO1 est un gène codé par le symbole GLO1. Communément appelé aussi: Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase. GLO1 a une masse de 20.78kDa et une longueur d'acide aminé de 184.
Nous proposons 2 GLO1 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.
Résumé Entrez
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere.
Similitudes de séquence
Belongs to the glyoxalase I family.
Modification post-traductionnelle
Glutathionylation at Cys-139 inhibits enzyme activity.
Liens de base de données
