GM-CSF est un gène codé par le symbole CSF2. Communément appelé aussi: Granulocyte-macrophage colony-stimulating factor; Colony-stimulating factor; CSF; Molgramostin; Sargramostim; CSF2; GMCSF. GM-CSF a une masse de 16.3kDa et une longueur d'acide aminé de 144.
Nous proposons 4 GM-CSF protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Résumé Entrez
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.
Similitudes de séquence
Belongs to the GM-CSF family.
Localisation cellulaire
Secreted.
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