GRO alpha est un gène codé par le symbole CXCL1. Communément appelé aussi: Growth-regulated alpha protein; C-X-C motif chemokine 1; GRO-alpha(1-73); Melanoma growth stimulatory activity; MGSA; Neutrophil-activating protein 3; NAP-3; CXCL1; GRO; GRO1; GROA; SCYB1. GRO alpha a une masse de 11.3kDa et une longueur d'acide aminé de 107.
Nous proposons 5 GRO alpha protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.
Résumé Entrez
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4.
Similitudes de séquence
Belongs to the intercrine alpha (chemokine CxC) family.
Modification post-traductionnelle
N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Localisation cellulaire
Secreted.
Liens de base de données
