Iba1 est un gène codé par le symbole AIF1. Communément appelé aussi: Allograft inflammatory factor 1; AIF-1; Ionized calcium-binding adapter molecule 1; Protein G1; AIF1; G1. Iba1 a une masse de 16.7kDa et une longueur d'acide aminé de 147.
Nous proposons 1 Iba1 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Résumé Entrez
This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain.
Spécificité tissulaire
Detected in T-lymphocytes and peripheral blood mononuclear cells.
Modification post-traductionnelle
Phosphorylated on serine residues.
Localisation cellulaire
Cytoplasm > Cytoskeleton. Cell projection > Ruffle membrane. Cell projection > Phagocytic cup.
Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
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