IGFBP1 est un gène codé par le symbole IGFBP1. Communément appelé aussi: Insulin-like growth factor-binding protein 1; IBP-1; Placental protein 12; PP12; IBP1. IGFBP1 a une masse de 27.9kDa et une longueur d'acide aminé de 259.
Nous proposons 2 IGFBP1 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
Résumé Entrez
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients.
Modification post-traductionnelle
Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.
Localisation cellulaire
Secreted.
Liens de base de données
