KGF est un gène codé par le symbole FGF7. Communément appelé aussi: Fibroblast growth factor 7; FGF-7; Heparin-binding growth factor 7; HBGF-7; Keratinocyte growth factor; FGF7. KGF a une masse de 22.51kDa et une longueur d'acide aminé de 194.
Nous proposons 3 KGF protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.
Résumé Entrez
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
Spécificité tissulaire
Epithelial cell.
Similitudes de séquence
Belongs to the heparin-binding growth factors family.
Localisation cellulaire
Secreted.
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