LACTB est un gène codé par le symbole LACTB. Communément appelé aussi: Serine beta-lactamase-like protein LACTB, mitochondrial; MRPL56. LACTB a une masse de 60.69kDa et une longueur d'acide aminé de 547.
Nous proposons 2 LACTB protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758).
Résumé Entrez
This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
Spécificité tissulaire
Expressed predominantly in skeletal muscle.
Similitudes de séquence
Belongs to the peptidase S12 family.
Localisation cellulaire
Mitochondrion.
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