LCN1 est un gène codé par le symbole LCN1. Communément appelé aussi: Lipocalin-1; Tear lipocalin; Tlc; Tear prealbumin; TP; von Ebner gland protein; VEG protein; VEGP. LCN1 a une masse de 19.25kDa et une longueur d'acide aminé de 176.
Nous proposons 1 LCN1 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.
Résumé Entrez
This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9.
Spécificité tissulaire
Mainly expressed in lachrymal and salivary glands. Also expressed in the prostate.
Similitudes de séquence
Belongs to the calycin superfamily. Lipocalin family.
Localisation cellulaire
Secreted.
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