LIF est un gène codé par le symbole LIF. Communément appelé aussi: Leukemia inhibitory factor; Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor; MLPLI; HILDA. LIF a une masse de 22.01kDa et une longueur d'acide aminé de 202.
Nous proposons 6 LIF protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Résumé Entrez
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Similitudes de séquence
Belongs to the LIF/OSM family.
Localisation cellulaire
Secreted.
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