Lymphotactin est un gène codé par le symbole XCL1. Communément appelé aussi: ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1; XCL1; LTN; SCYC1. Lymphotactin a une masse de 12.52kDa et une longueur d'acide aminé de 114.
Nous proposons 2 Lymphotactin protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
Résumé Entrez
This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1.
Spécificité tissulaire
Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.
Similitudes de séquence
Belongs to the intercrine gamma family.
Localisation cellulaire
Secreted.
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