Osteopontin est un gène codé par le symbole SPP1. Communément appelé aussi: Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Uropontin; SPP1; BNSP; OPN. Osteopontin a une masse de 35.42kDa et une longueur d'acide aminé de 314.
Nous proposons 1 Osteopontin protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
Résumé Entrez
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Bone. Found in plasma.
Similitudes de séquence
Belongs to the osteopontin family.
Modification post-traductionnelle
Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif.
Localisation cellulaire
Secreted.
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