Persephin est un gène codé par le symbole PSPN. Communément appelé aussi: PSP; PSPN. Persephin a une masse de 16.6kDa et une longueur d'acide aminé de 156.
Nous proposons 2 Persephin protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.
Résumé Entrez
This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Elevated expression of this gene has been observed in oral squamous cell carcinoma.
Similitudes de séquence
Belongs to the TGF-beta family. GDNF subfamily.
Localisation cellulaire
Secreted.
Liens de base de données
