Phospholipase A2 X est un gène codé par le symbole PLA2G10. Communément appelé aussi: Group 10 secretory phospholipase A2; Group X secretory phospholipase A2; GX sPLA2; Phosphatidylcholine 2-acylhydrolase 10; PLA2G10. Phospholipase A2 X a une masse de 18.15kDa et une longueur d'acide aminé de 165.
Nous proposons 1 Phospholipase A2 X protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
Résumé Entrez
This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism.
Spécificité tissulaire
Found in spleen, thymus, peripheral blood leukocytes, pancreas, lung, and colon.
Similitudes de séquence
Belongs to the phospholipase A2 family.
Localisation cellulaire
Secreted.
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