PLGF est un gène codé par le symbole PGF. Communément appelé aussi: Placenta growth factor; PGF; PGFL. PLGF a une masse de 24.79kDa et une longueur d'acide aminé de 221.
Nous proposons 3 PLGF protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
Résumé Entrez
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.
Spécificité tissulaire
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
Similitudes de séquence
Belongs to the PDGF/VEGF growth factor family.
Modification post-traductionnelle
N-glycosylated.
Localisation cellulaire
Secreted.
The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
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