PPM1A est un gène codé par le symbole PPM1A. Communément appelé aussi: Protein phosphatase 1A; Protein phosphatase 2C isoform alpha; PP2C-alpha; Protein phosphatase IA; PPPM1A. PPM1A a une masse de 42.45kDa et une longueur d'acide aminé de 382.
Nous proposons 1 PPM1A protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Résumé Entrez
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Similitudes de séquence
Belongs to the PP2C family.
Modification post-traductionnelle
N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
Localisation cellulaire
Nucleus. Cytoplasm > Cytosol. Membrane.
Weakly associates at the membrane and N-myristoylation mediates the membrane localization.
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