SAA1 est un gène codé par le symbole SAA1. Il est également connu sous le nom de: Serum amyloid A-1 protein; SAA. SAA1 a une masse de 13.53kDa et une longueur d'acide aminé de 122.
Nous proposons 2 SAA1 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Major acute phase protein.
Résumé Entrez
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
Spécificité tissulaire
Expressed by the liver; secreted in plasma (at protein level).
Similitudes de séquence
Belongs to the SAA family.
Modification post-traductionnelle
This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
Localisation cellulaire
Secreted.
Liens de base de données
