Stanniocalcin 2 est un gène codé par le symbole STC2. Il est également connu sous le nom de: Stanniocalcin-2; STC-2; Stanniocalcin-related protein; STC-related protein; STC2. Stanniocalcin 2 a une masse de 33.25kDa et une longueur d'acide aminé de 302.
Nous proposons 2 Stanniocalcin 2 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
Résumé Entrez
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.
Spécificité tissulaire
Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.
Similitudes de séquence
Belongs to the stanniocalcin family.
Localisation cellulaire
Secreted.
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