TNFSF18 est un gène codé par le symbole TNFSF18. Il est également connu sous le nom de: Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL; GITRL; TL6. TNFSF18 a une masse de 22.72kDa et une longueur d'acide aminé de 199.
Nous proposons 3 TNFSF18 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
Résumé Entrez
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.
Spécificité tissulaire
Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Similitudes de séquence
Belongs to the tumor necrosis factor family.
Localisation cellulaire
Cell membrane.
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