UBA2 est un gène codé par le symbole UBA2. Il est également connu sous le nom de: SUMO-activating enzyme subunit 2; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2; SAE2; UBLE1B. UBA2 a une masse de 71.22kDa et une longueur d'acide aminé de 640.
Nous proposons 1 UBA2 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Résumé Entrez
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999
Similitudes de séquence
Belongs to the ubiquitin-activating E1 family.
Modification post-traductionnelle
Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking.
Localisation cellulaire
Cytoplasm. Nucleus.
Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
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