Anti-RBP4 Anticorps [RBP4/4314] (A249844)

Name: Anti-RBP4 Antibody [RBP4/4314]
Brand: Antibodies.com
SKU: A249844
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [RBP4/4314] de souris contre RBP4 pour WB et IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

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Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

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Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-RBP4 Antibody [RBP4/4314]

Description du produit

Mouse monoclonal [RBP4/4314] antibody to RBP4.

Spécificité

Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal Vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP, resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with Insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity.

Applications

WB, IHC-P

Recommander des dilutions

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant fragment, around amino acids 29-148, of human RBP4 protein. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

RBP4/4314

Isotype

IgG2b

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

25 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-RBP4 Antibody [RBP4/4314] - BSA and Azide free (A253024).

Synonymes

OTTHUMP00000020114, OTTHUMP00000020115, OTTHUMP00000020116, Plasma retinol binding protein 4, Plasma retinol-binding protein, Plasma retinol-binding protein(1-176), PRBP, PRO2222, RBP, RDCCAS, RET4_HUMAN, Retinol binding protein 4, Retinol binding protein 4 interstitial, Retinol binding protein 4 plasma

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (4)

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Figure 1: Western Blot - Anti-RBP4 Antibody [RBP4/4314] (A249844)

Western blot analysis of human kidney and liver tissue lysates using Anti-RBP4 Antibody [RBP4/4314].

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Figure 2: Western Blot - Anti-RBP4 Antibody [RBP4/4314] (A249844)

Western blot analysis of human pancreas tissue lysate using Anti-RBP4 Antibody [RBP4/4314].

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Figure 3: Immunohistochemistry - Anti-RBP4 Antibody [RBP4/4314] (A249844)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human kidney using Anti-RBP4 Antibody [RBP4/4314].

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Figure 4: Anti-RBP4 Antibody [RBP4/4314] (A249844)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-RBP4 Antibody [RBP4/4314]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.