Anti-SIRT1 Anticorps [PCRP-SIRT1-1E11] (A278204)

Anticorps monoclonal [PCRP-SIRT1-1E11] de souris contre SIRT1 pour ELISA, IP, Flow Cytometry, IF et WB.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-SIRT1 Antibody [PCRP-SIRT1-1E11] - BSA and Azide free
Description du produit
Mouse monoclonal [PCRP-SIRT1-1E11] antibody to SIRT1.
Spécificité
The silent information regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent matingtype loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologs, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues, with high expression in heart, brain and skeletal muscle and low expression in lung and placenta. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lysine 382.
Applications
ELISA, IP, Flow Cytometry, IF, WB
Recommander des dilutions
IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant full-length human SIRT1 protein.
Hôte
Mouse
Clonalité
Monoclonal
Clone
PCRP-SIRT1-1E11
Isotype
IgG1
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Masse moléculaire
120 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Notes générales
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-SIRT1 Antibody [PCRP-SIRT1-1E11] (A277616).
Synonymes
75SirT1, hSIR2, hSIRT1, HST2, S. cerevisiae, homolog of, NAD dependent deacetylase sirtuin 1, NAD dependent protein deacetylase sirtuin 1, NAD-dependent deacetylase sirtuin-1, OTTHUMP00000198111, OTTHUMP00000198112, Regulatory protein SIR2 homolog 1, SIR1_HUMAN, SIR2, SIR2 like 1, SIR2 like protein 1, SIR2, S.cerevisiae, homolog-like 1, SIR2-like protein 1, SIR2ALPHA, SIR2L1, SIRT1_HUMAN, SirtT1 75 kDa fragment, Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), Sirtuin 1, sirtuin 1 ((silent mating type information regulation 2 homolog) 1, Sirtuin type 1
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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