Anti-STAT2 (phospho Tyr690) Anticorps (A283679)

Anti-STAT2 (phospho Tyr690) Antibody

Rabbit polyclonal antibody to STAT2 (phospho Tyr690).

This antibody recognises STAT2, also known as p113 when phosphorylated at tyrosine 690. STAT2 is a member of the STAT family of transcription factors. Upon ligand binding receptor associated kinases phosphorylate STATs causing them to dimerize and translocate to the nucleus. STAT2 forms a heterodimer with STAT1 where promotes transcription at interferon-sensitive response elements. Phosphorylation of STAT2 at tyrosine 690 by JAKs promotes the dimerization with STAT1.

WB

WB: 1:500 - 1:1,000

Human

Phospho-specific peptide corresponding to residues surrounding Tyr690 of human STAT2.

Rabbit

Polyclonal

IgG

Unconjugated

Liquid

Supplied in Phosphate Buffered Saline with 0.05% ProClin 300 and 50% Glycerol.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti STAT2 (pTyr690) antibody recognizes STAT2, also known as p113 when phosphorylated at tyrosine 690. STAT2 is a member of the STAT family of transcription factors. Upon ligand binding receptor associated kinases phosphorylate STATs causing them to dimerize and translocate to the nucleus. STAT2 forms a heterodimer with STAT1 where promotes transcription at interferon-sensitive response elements. Phosphorylation of STAT2 at tyrosine 690 by JAKs promotes the dimerization with STAT1.

Homo sapiens interferon alpha induced transcriptional activator, interferon alpha induced transcriptional activator, ISGF 3, ISGF3, MGC59816, P113, Signal transducer and activator of transcription 2, signal transducer and activator of transcription 2 113kD, STAT113, STAT2_HUMAN