Anti-Superoxide Dismutase 1 Anticorps [SOD1/3923] (A277795)

Anticorps monoclonal [SOD1/3923] de souris contre Superoxide Dismutase 1 pour Flow Cytometry, IF et IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-Superoxide Dismutase 1 Antibody [SOD1/3923]
Description du produit
Mouse monoclonal [SOD1/3923] antibody to Superoxide Dismutase 1.
Spécificité
Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.
Applications
Flow Cytometry, IF, IHC-P
Recommander des dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant full-length human SOD1 protein.
Hôte
Mouse
Clonalité
Monoclonal
Clone
SOD1/3923
Isotype
IgG2b
Chaînes légères
kappa
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Masse moléculaire
16 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Notes générales
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Superoxide Dismutase 1 Antibody [SOD1/3923] - BSA and Azide free (A278383).
Synonymes
ALS, ALS1, Amyotrophic Lateral Sclerosis 1 (Adult), Amyotrophic lateral sclerosis 1 adult, Cu,Zn Superoxide Dismutase, EC 1.15.1.111, Cu/Zn SOD, Cu/Zn superoxide dismutase, Epididymis secretory protein Li 44, HEL S 44, Homodimer, hSod1, Indophenoloxidase A, IPOA, Mn superoxide dismutase, SOD, SOD soluble, SOD1, SOD2, SODC, SODC_HUMAN, Superoxide dismutase 1 soluble, Superoxide Dismutase 1, Soluble, Superoxide dismutase Cu Zn, Superoxide dismutase cystolic, Superoxide dismutase [Cu-Zn], Superoxide Dismutase, Cystolic
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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