This antibody recognises an extracellular domain of the ~55 kDa human TNF receptor (p55, TNF-R1, CD120a). No binding occurs to the ~75 kDa TNF receptor (CD120b). CD120a is weakly expressed by monocytes and granulocytes. Mouse anti Human CD120a antibody, clone H398 may be used to detect high levels of TNFR1, in western blotting under reducing conditions, such as recombinant material, but it is not suitable for detection of TNFR1 in normal cells in this application. Mouse anti Human CD120a antibody, clone H398 inhibits the biological activity of both natural and recombinant human TNFalpha and TNFbeta (Thoma et al. 1990 and Dri et al. 1999). Mouse anti Human CD120a antibody, clone H398 is routinely tested in flow cytometry on human peripheral blood monocytes.

Applications

ELISA, RIA

Reactivité

Human, Rabbit

Immunogène

Purified human tumour necrosis factor receptor type 1.

Hôte

Mouse

Clonalité

Monoclonal

Clone

H398

Isotype

IgG2a

Conjuguer

Unconjugated

Purification

Protein A affinity chromatography of tissue culture supernatant.

Concentration

1 mg/ml

Forme du produit

Liquid

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Stockage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Notes générales

Mouse anti Human CD120a antibody, clone H398 recognizes an extracellular domain of the ~55 kDa human TNF receptor (p55, TNF-R1, CD120a). No binding occurs to the ~75 kDa TNF receptor (CD120b). CD120a is weakly expressed by monocytes and granulocytes.Mouse anti Human CD120a antibody, clone H398 may be used to detect high levels of TNFR1, in western blotting under reducing conditions, such as recombinant material, but it is not suitable for detection of TNFR1 in normal cells in this application.Mouse anti Human CD120a antibody, clone H398 inhibits the biological activity of both natural and recombinant human TNFalpha and TNFbeta (Thoma et al. 1990 and Dri et al. 1999).Mouse anti Human CD120a antibody, clone H398 is routinely tested in flow cytometry on human peripheral blood monocytes.

Synonymes

CD120a, FPF, MGC19588, p55, p55-R, p60, TBP1, TBPI, TNF R, TNF R55, TNF-R1, TNF-RI, TNFAR, TNFR-I, TNFR1, TNFR55, TNFR60, TNFRI, TNFRSF1a, TNR1A_HUMAN, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor superfamily, member 1A, Tumor necrosis factor receptor type 1, Tumor necrosis factor receptor type I, Tumor necrosis factor-binding protein 1

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.