Anti-ZAP70 (phospho Tyr493) Anticorps (A283686)

Anti-ZAP70 (phospho Tyr493) Antibody

Rabbit polyclonal antibody to ZAP70 (phospho Tyr493).

This antibody recognises ZAP 70, also known as Zeta-chain-associated protein kinase 70 when phosphorylated at tyrosine 493. ZAP70 is a member of the tyrosine kinase family. ZAP 70 plays a key role in the activation of T cells. ZAP 70 is phosphorylated at tyrosine 493 by Lck in response to T cell receptor stimulation. Phosphorylation of ZAP 70 at tyrosine 493 fully activates ZAP 70 leading to phosphorylation of downstream targets of the T cell activation pathway.

WB, IHC-P

IHC-P: 1:50 - 1:100, WB: 1:500 - 1:2,000

Human, Mouse, Rat

Phospho-specific peptide corresponding to residues surrounding Tyr493 of human ZAP 70.

Rabbit

Polyclonal

IgG

Unconjugated

Lot Specific

Supplied in Phosphate Buffered Saline with 0.05% ProClin 300 and 50% Glycerol.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti ZAP 70 (pTyr493) antibody recognizes ZAP 70, also known as Zeta-chain-associated protein kinase 70 when phosphorylated at tyrosine 493. ZAP70 is a member of the tyrosine kinase family. ZAP 70 plays a key role in the activation of T cells. ZAP 70 is phosphorylated at tyrosine 493 by Lck in response to T cell receptor stimulation (Wang et al. 2010). Phosphorylation of ZAP 70 at tyrosine 493 fully activates ZAP 70 leading to phosphorylation of downstream targets of the T cell activation pathway.

70 kDa zeta associated protein, 70 kDa zeta-associated protein, 70 KDa Zeta-Associated Protein2, 70 KDa Zeta-Chain Associated Protein, EC 2.7.10, EC 2.7.10.2, FLJ17670, FLJ17679, Selective T cell defect, SRK, STCD, STD, Syk related tyrosine kinase, Syk-related tyrosine kinase, Truncated ZAP kinase, Tyrosine protein kinase ZAP70, Tyrosine-protein kinase ZAP-70, TZK, ZAP 70, ZAP-70, ZAP70_HUMAN, Zeta chain associated protein kinase 70kD, Zeta chain associated protein kinase 70kDa, Zeta chain associated protein kinase 70kDa isoform 1, Zeta chain associated protein kinase 70kDa isoform 2, Zeta chain of T cell receptor associated protein kinase 70, Zeta chain TCR associated protein kinase 70kD, Zeta chain TCR associated protein kinase 70kDa, Zeta-Chain (TCR) Associated ProteinKinase (70 KD), Zeta-Chain Associated Protein Kinase, 70kD