Anti-GSK3 beta (phospho Tyr216) Antibody (A283625)

Anti-GSK3 beta (phospho Tyr216) Antibody

Rabbit polyclonal antibody to GSK3 beta (phospho Tyr216).

This antibody recognises GSK3 beta when phosphorylated at tyrosine 216. GSK3 is a member of the CMGC family of kinases. GSK3 comprises two isoforms, alpha and beta, with 85% total homology and 98% homology between kinase domains. GSK3 beta is phosphorylated at tyrosine 216 via autophosphorylation, Fyn and PYK2. Phosphorylation of GSK3 beta at tyrosine 216 activates GSK3 alpha leading to phosphorylation of downstream targets such as the insulin receptor and glucose-6-phosphate.

WB, IHC-P

IHC-P: 1:50 - 1:100, WB: 1:500 - 1:2,000

Human, Mouse, Rat

Phospho-specific peptide corresponding to residues surrounding Tyr216 of human GSK3 beta.

Rabbit

Polyclonal

IgG

Unconjugated

Liquid

Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti GSK3 Beta (pTyr216) antibody recognizes GSK3 beta when phosphorylated at tyrosine 216. GSK3 is a member of the CMGC family of kinases. GSK3 comprises two isoforms, alpha and beta, with 85% total homology and 98% homology between kinase domains. GSK3 beta is phosphorylated at tyrosine 216 via autophosphorylation, Fyn and PYK2. Phosphorylation of GSK3 beta at tyrosine 216 activates GSK3 alpha leading to phosphorylation of downstream targets such as the insulin receptor and glucose-6-phosphate.

Glycogen Synthase Kinase 3 Beta, Glycogen synthase kinase-3 beta, GSK 3 beta, GSK-3 beta, GSK3B, GSK3beta isoform, GSK3B_HUMAN, Serine/threonine-protein kinase GSK3B