Anti-IL-17 Antibody [TC11-18H10] (A281814)

Anti-IL-17 Antibody [TC11-18H10]

Rat anti Mouse Interleukin-17

Rat anti Mouse interleukin-17 antibody, clone TC11-18H10 recognises mouse Interleukin 17, a ~32 kDa disulfide-linked homodimer consisting of two 136 amino acid chains, which belong to the IL-17 family (classified as IL-17A to IL-17F), and signal through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNF-alpha, IFN-gamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction.

Flow Cytometry, WB, ELISA

Mouse

Rat

Monoclonal

TC11-18H10

Affinity chromatography.

500 µg/ml

Liquid

Supplied in Borate Buffered Saline; without preservative.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL17A, Interleukin-17A