Anti-CD146 Antibody [C146/634] (A249292)

Anti-CD146 Antibody [C146/634]

Mouse monoclonal [C146/634] antibody to CD146.

The human CD146 gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. CD146 is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

Flow Cytometry, IF, IHC-P

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant human CD146 protein.

Mouse

Monoclonal

C146/634

IgG1

kappa

200 µg/ml

130 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD146 Antibody [C146/634] - BSA and Azide free (A252472).

Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12, MCAM, Melanoma cell adhesion molecule, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, MUC18, S-endo 1 endothelial-associated antigen