Anti-HER2 Antibody [SPM172] (A248444)

Anti-HER2 Antibody [SPM172]

Mouse monoclonal [SPM172] antibody to HER2.

This antibody recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 311-462, of human HER2 protein. The exact sequence is proprietary.

Mouse

Monoclonal

SPM172

IgG

kappa

Protein A/G chromatography.

200 µg/ml

185 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-HER2 Antibody [SPM172] - BSA and Azide free (A251626).

CD340, Metastatic lymph node gene 19 protein, MLN 19, MLN19, NEU, NGL, p185erbB2, Proto-oncogene c-ErbB-2, Proto-oncogene Neu, Receptor tyrosine-protein kinase erbB-2, Tyrosine kinase-type cell surface receptor HER2