This antibody recognises human Autophagy-related protein 7, known also as Ubitiquin Activating Enzyme-E1 like Protein, ATG7, and APG7. ATG7 is a ~78 kDa cytoplasmic protein.In mammalian cells, ATG7 is essential for autophagy conjugation systems, autophagosome formation, and starvation-induced bulk degradation of proteins and organelles. Caspase-8 may alter ATG7 levels and thus the ATG7 program of autophagic cell death. ATG7 is evolutionarily conserved exhibiting high homology within mammalian species. It expressed in wide range of tissues including kidney, liver, bone marrow and lymph nodes.

Anwendungen

WB, IHC-Fr

Verdünnungen

IHC-Fr: 10 µg/ml, WB: 1 - 2 µg/ml

Reaktivität

Human, Mouse

Immunogen

A peptide corresponding to 17 amino acids near the C-terminus of human ATG7.

Wirt

Rabbit

Klonalität

Polyclonal

Isotyp

IgG

Konjugat

Unconjugated

Konzentration

1 mg/ml

Molekulargewicht

Approximately 78 kDa in Caco-2 cell lysate.

Produktform

Liquid

Formulierung

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Lagerung

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Allgemeine Hinweise

Rabbit anti Human ATG7 (C-Terminal) antibody recognizes human Autophagy-related protein 7, known also as Ubitiquin Activating Enzyme-E1 like Protein, ATG7, and APG7. ATG7 is a ~78 kDa cytoplasmic protein.In mammalian cells, ATG7 is essential for autophagy conjugation systems, autophagosome formation, and starvation-induced bulk degradation of proteins and organelles. Caspase-8 may alter ATG7 levels and thus the ATG7 program of autophagic cell death (Yu et al. 2004).ATG7 is evolutionarily conserved exhibiting high homology within mammalian species. It expressed in wide range of tissues including kidney, liver, bone marrow and lymph nodes.

Synonyme

1810013K23Rik, Apg 7, Apg7, APG7 autophagy 7 like, APG7 autophagy 7-like (S. cerevisiae), APG7 like, APG7, S. cerevisiae, homolog of, APG7-like, APG7L, ATG 7, ATG12-activating enzyme E1 ATG7, ATG7 autophagy related 7 homolog, ATG7 autophagy related 7 homolog (S. cerevisiae), Atg7l, ATG7_HUMAN, Autophagy 7, S. cerevisiae, homolog of, Autophagy related protein 7, Autophagy-related 7 (yeast), Autophagy-related protein 7, DKFZp434N0735, GSA 7, GSA7, hAGP7, Ubiquitin activating enzyme E1 like protein, Ubiquitin-activating enzyme E1-like protein, Ubiquitin-like modifier-activating enzyme ATG7

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.