MAP2 ist ein Gen, das durch das Symbol MAP2 kodiert wird. Im Allgemeinen auch bezeichnet als: Microtubule-associated protein 2; MAP-2. MAP2 hat eine Masse von 199.53kDa und eine Aminosäurelänge von 1827.
Wir bieten 27 antikörper gegen MAP2, aufgewachsen in Kaninchen, Maus, Ziege und Huhn, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus, Ratte, Rind, Schwein und Katze.
Gen- und Proteininformationen
UniProt Zusammenfassung
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Entrez Zusammenfassung
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
Posttranslationale Modifikation
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).
Zellort
Cytoplasm > Cytoskeleton. Cell projection > Dendrite.
