Anti-beta 2 Microglobulin Anticorps [C21.48A1] (A249751)

Anti-beta 2 Microglobulin Antibody [C21.48A1]

Mouse monoclonal [C21.48A1] antibody to beta 2 Microglobulin.

The antibody recognizes the hidden determinant of beta-2 microglobulin (i.e. binding to its determinant is available only when the chain is separated from the HLA heavy chain. Beta-2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkins lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Beta2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).

Flow Cytometry, WB, IF

Flow Cytometry: 1-2 µg/million cells, WB: 1-2 µg/ml, IF: 1-2 µg/ml

Human, Non-Human Primates

Soluble beta 2 microglobulin.

Mouse

Monoclonal

C21.48A1

IgG2b

Unconjugated

Protein A/G chromatography.

200 µg/ml

12 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-beta 2 Microglobulin Antibody [C21.48A1] - BSA and Azide free (A252931).

B2M, B2MG_HUMAN, Beta 2 microglobin, Beta 2 microglobulin precursor , Beta chain of mhc class 1 proteins , Beta chain of MHC class I molecules, Beta-2-microglobulin form pI 5.3, CDABP0092, Hdcma22p, IMD43