CD89 est un gène codé par le symbole FCAR. D'autres noms incluent: Immunoglobulin alpha Fc receptor; IgA Fc receptor; FCAR. CD89 a une masse de 32.27kDa et une longueur d'acide aminé de 287.
Nous proposons 13 des anticorps contre CD89, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Primates.
Informations sur les Gènes et les Protéines
Résumé UniProt
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Résumé Entrez
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Spécificité tissulaire
Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.
Localisation cellulaire
Cell membrane.
