Histone H3 est un gène codé par le symbole H3-IX. Communément appelé aussi: Histone H3.3; H3-IX. Histone H3 a une masse de 15.33kDa, une longueur d'acide aminé de 136, et est impliqué dans Glioma.
Nous proposons 224 des anticorps contre Histone H3, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP, Dot et ChIP avec des échantillons dérivés de Humain, Souris, Rat, Singe et Poisson Zèbre.
Informations sur les Gènes et les Protéines
Résumé UniProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Résumé Entrez
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This histone pseudogene is found in the large histone gene cluster on chromosome 6.
Spécificité tissulaire
Low levels of expression in ovaries and moderate levels of expression in the testes. Highest levels of expression in embryos.
Implication dans la maladie
Glioma: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Similitudes de séquence
Belongs to the histone H3 family.
Modification post-traductionnelle
Acetylation is generally linked to gene activation.
Localisation cellulaire
Nucleus. Chromosome.