Histone H4 est un gène codé par le symbole H4C1. Communément appelé aussi: H4C1; H4/A; H4FA; HIST1H4A. Histone H4 a une masse de 11.37kDa et une longueur d'acide aminé de 103.
Nous proposons 71 des anticorps contre Histone H4, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP, Dot et ChIP avec des échantillons dérivés de Humain, Souris, Rat, Singe, Drosophile et Plantes.
Informations sur les Gènes et les Protéines
Résumé UniProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Résumé Entrez
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element.
Similitudes de séquence
Belongs to the histone H4 family.
Modification post-traductionnelle
Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
Localisation cellulaire
Nucleus. Chromosome.
