MAP2 est un gène codé par le symbole MAP2. Communément appelé aussi: Microtubule-associated protein 2; MAP-2. MAP2 a une masse de 199.53kDa et une longueur d'acide aminé de 1827.
Nous proposons 27 des anticorps contre MAP2, élevé dans Lapin, Souris, Chèvre et Poulet, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin et Félin.
Informations sur les Gènes et les Protéines
Résumé UniProt
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Résumé Entrez
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
Modification post-traductionnelle
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).
Localisation cellulaire
Cytoplasm > Cytoskeleton. Cell projection > Dendrite.
