Rab5 est un gène codé par le symbole RAB5A. Il est également connu sous le nom de Ras-related protein Rab-5AA. Rab5 a une masse de 23.66kDa et une longueur d'acide aminé de 215.
Nous proposons 17 des anticorps contre Rab5, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Singe et Canin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
Similitudes de séquence
Belongs to the small GTPase superfamily. Rab family.
Modification post-traductionnelle
Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including RAB GDP dissociation inhibitors GDI1 and GDI2.
Localisation cellulaire
Cell membrane. Early endosome membrane. Melanosome. Cytoplasmic vesicle. Cell projection > Ruffle. Membrane. Cytoplasm > Cytosol. Cytoplasmic vesicle > Phagosome membrane. Endosome membrane.
Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable).
