MAP2 è un gene codificato dal simbolo MAP2. Comunemente indicato anche come: Microtubule-associated protein 2; MAP-2. MAP2 ha una massa di 199.53kDa e una lunghezza di amminoacidi di 1827.
Offriamo 27 anticorpi contro MAP2, allevati nel Coniglio, Topo, Capra e Pollo, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo, Ratto, Bovino, Maiale e Gatto.
Informazioni su geni e proteine
Riepilogo UniProt
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Sommario di Entrez
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
Modifica post-translazionale
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).
Posizione cellulare
Cytoplasm > Cytoskeleton. Cell projection > Dendrite.
