Anti-AKT1 (phospho Thr450) Anticorps (A283548)

Anti-AKT1 (phospho Thr450) Antibody

Rabbit polyclonal antibody to AKT1 (phospho Thr450).

This antibody recognises AKT1, also known as RAC-alpha serine/threonine-protein kinase, protein kinase B alpha or Proto-oncogene c-Akt, when phosphorylated at threonine 450. AKT1 is a 480 amino acid ~48 kDa protein kinase that play a key role in the PI3K-Akt signaling pathway, known to regulate cell growth, proliferation and survival. Phosphorylation of threonine 308 and serine 473 are required for full activation of AKT1. Newly synthesized Akt is suggested to require phosphorylation at threonine 450 for proper protein folding.

WB

WB: 1:500 - 1:1,000

Human

Phospho-specific peptide corresponding to residues surrounding Thr450 of human AKT1.

Rabbit

Polyclonal

IgG

Unconjugated

Liquid

Supplied in Phosphate Buffered Saline with 0.05% ProClin 300 and 50% Glycerol.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti AKT1 (pThr450) antibody recognizes AKT1, also known as RAC-alpha serine/threonine-protein kinase, protein kinase B alpha or Proto-oncogene c-Akt, when phosphorylated at threonine 450. AKT1 is a 480 amino acid ~48 kDa protein kinase that play a key role in the PI3K-Akt signaling pathway, known to regulate cell growth, proliferation and survival. Phosphorylation of threonine 308 and serine 473 are required for full activation of AKT1. Newly synthesized Akt is suggested to require phosphorylation at threonine 450 for proper protein folding (Liao and Hung 2010).

AKT, AKT 1, AKT1_HUMAN, MGC99656, PKB, PKB-ALPHA, PRKBA, Protein kinase B, Protein Kinase B Alpha, Proto-oncogene c-Akt, RAC, RAC Alpha, RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha