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Anti-GAPDH (1A6) Antibody

Total Citations (104)
Mouse monoclonal antibody to GAPDH (1A6) from Bioworld Technology (MB001).
Name: Anti-GAPDH (1A6) Antibody
Description: Mouse monoclonal antibody to GAPDH (1A6)
Specificity: GAPDH (1A6) mAb detects endogenous levels of GAPDH protein.
Applications: ELISA, WB, IHC, IF
Reactivity: Human, Mouse, Rabbit, Frog, Fish, Chicken, Rat
Immunogen: Recombinant full length Human GAPDH.
Host: Mouse
Clonality: Monoclonal
Conjugate: Unconjugated
Molecular Weight: ~ 36 kDa
Purity: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Introduction: Glyceraldehyde 3 phosphate dehydrogenase (GAPDH) is well known as one of the key enzymes involved in glycolysis. As well as functioning as a glycolytic enzyme in cytoplasm, recent evidence suggests that mammalian GAPDH is also involved in a great number of intracellular proceses such as membrane fusion, microtubule bundling, phosphotransferase activity, nuclear RNA export, DNA replication, and DNA repair. During the last decade a lot of data appeared concerning the role of GAPDH in different pathologies including prostate cancer progression, programmed neuronal cell death, age related neuronal diseases, such as Alzheimer's and Huntington's disease. GAPDH is expressed in all cells. It is constitutively expressed in almost all tissues at high levels.
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For details please refer to datasheet.
For details please refer to datasheet.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.

C-C Motif Chemokine Receptor 9 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. J Am Heart Assoc (2016) 5 5:

Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure Overload-Induced Cardiac Hypertrophy. J Am Heart Assoc (2016) 5 2:

Tripartite motif 32 prevents pathological cardiac hypertrophy. Clin. Sci. (2016) May 1 130 10: 813-28

Yangjing Capsule Ameliorates Spermatogenesis in Male Mice Exposed to Cyclophosphamide. Evid Based Complement Alternat Med (2015) 2015 : 980583

Pluripotency-associated miR-290/302 family of microRNAs promote the dismantling of naive pluripotency. Cell Res. (2016) Mar 26 3: 350-66

S1PR1 expression correlates with inflammatory responses to Newcastle disease virus infection. Infect. Genet. Evol. (2016) Jan 37 : 37-42

The anti-tumour activity of rLj-RGD4, an RGD toxin protein from Lampetra japonica, on human laryngeal squamous carcinoma Hep-2 cells in nude mice. Biochimie (2015) Dec 119 : 183-91

Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development. Cell Rep (2015) Oct 27 13 4: 723-32

Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. Proc. Natl. Acad. Sci. U.S.A. (2015) Nov 3 112 44: 13627-32

Paeonol inhibits B16F10 melanoma metastasis in vitro and in vivo via disrupting proinflammatory cytokines-mediated NF-B and STAT3 pathways. IUBMB Life (2015) Oct 67 10: 778-88

Afatinib reverses multidrug resistance in ovarian cancer via dually inhibiting ATP binding cassette subfamily B member 1. Oncotarget (2015) Sep 22 6 28: 26142-60

Protective Effect of L-Theanine on Cadmium-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondria-Mediated Pathway. Neurochem. Res. (2015) Aug 40 8: 1661-70

A novel benzenediamine derivative FC98 reduces insulin resistance in high fat diet-induced obese mice by suppression of metaflammation. Eur. J. Pharmacol. (2015) Aug 15 761 : 298-308

Low-protein diet fed to crossbred sows during pregnancy and lactation enhances myostatin gene expression through epigenetic regulation in skeletal muscle of weaning piglets. Eur J Nutr (2016) Apr 55 3: 1307-14

Effect of advanced oxidation protein products on articular cartilage and synovium in a rabbit osteoarthritis model. Orthop Surg (2015) May 7 2: 161-7

Lithium chloride administration prevents spatial learning and memory impairment in repeated cerebral ischemia-reperfusion mice by depressing apoptosis and increasing BDNF expression in hippocampus. Behav. Brain Res. (2015) Sep 15 291 : 399-406

Malat1 regulates serum response factor through miR-133 as a competing endogenous RNA in myogenesis. FASEB J. (2015) Jul 29 7: 3054-64

Baicalein suppresses 17--estradiol-induced migration, adhesion and invasion of breast cancer cells via the G protein-coupled receptor 30 signaling pathway. Oncol. Rep. (2015) Apr 33 4: 2077-85

Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats. J. Cell. Physiol. (2015) Sep 230 9: 2184-201

MiR-130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells. BMC Cancer (2015) 15 : 29

Cystathionine--Synthase Gene Transfer Into Rostral Ventrolateral Medulla Exacerbates Hypertension via Nitric Oxide in Spontaneously Hypertensive Rats. Am. J. Hypertens. (2015) Sep 28 9: 1106-13

Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells. Acta Pharmacol. Sin. (2015) Feb 36 2: 259-67

Mechanism-based inhibitory and peroxisome proliferator-activated receptor -dependent modulating effects of silybin on principal hepatic drug-metabolizing enzymes. Drug Metab. Dispos. (2015) Apr 43 4: 444-54

S100A8 contributes to postoperative cognitive dysfunction in mice undergoing tibial fracture surgery by activating the TLR4/MyD88 pathway. Brain Behav. Immun. (2015) Feb 44 : 221-34

Crosstalk between JNK and NF-B signaling pathways via HSP27 phosphorylation in HepG2 cells. Biochem. Biophys. Res. Commun. (2015) Jan 2 456 1: 122-8

Transcriptional silencing of ETS-1 abrogates epithelial-mesenchymal transition resulting in reduced motility of pancreatic cancer cells. Oncol. Rep. (2015) Feb 33 2: 559-65

A recurrent deletion mutation in OPA1 causes autosomal dominant optic atrophy in a Chinese family. Sci Rep (2014) 4 : 6936

Apigenin inhibits enterovirus-71 infection by disrupting viral RNA association with trans-acting factors. PLoS ONE (2014) 9 10: e110429

Interferon regulatory factor 9 is critical for neointima formation following vascular injury. Nat Commun (2014) 5 : 5160

Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPAR factor and the NADPH oxidase/ROS-NF-B signal pathway. Toxicol. Lett. (2014) Oct 8 232 1: 149-158

Effect of surface topography and bioactive properties on early adhesion and growth behavior of mouse preosteoblast MC3T3-E1 cells. ACS Appl Mater Interfaces (2014) Oct 8 6 19: 17134-43

Effects of alltrans retinoic acid on VEGF and HIF1 expression in glioma cells under normoxia and hypoxia and its antiangiogenic effect in an intracerebral glioma model. Mol Med Rep (2014) Nov 10 5: 2713-9

Dahuang Fuzi Decoction ameliorates tubular epithelial apoptosis and renal damage via inhibiting TGF-1-JNK signaling pathway activation in vivo. J Ethnopharmacol (2014) Oct 28 156 : 115-24

Different strategies for producing naturally soluble form of common cytokine receptor chain. Dev. Comp. Immunol. (2015) Jan 48 1: 13-21

FOXA2 suppresses the metastasis of hepatocellular carcinoma partially through matrix metalloproteinase-9 inhibition. Carcinogenesis (2014) Nov 35 11: 2576-83

Ureic clearance granule, alleviates renal dysfunction and tubulointerstitial fibrosis by promoting extracellular matrix degradation in renal failure rats, compared with enalapril. J Ethnopharmacol (2014) Sep 29 155 3: 1541-52

Astaxanthin alleviates early brain injury following subarachnoid hemorrhage in rats: possible involvement of Akt/bad signaling. Mar Drugs (2014) Aug 12 8: 4291-310

PKM2 depletion induces the compensation of glutaminolysis through -catenin/c-Myc pathway in tumor cells. Cell. Signal. (2014) Nov 26 11: 2397-405

The transient expression of miR-203 and its inhibiting effects on skeletal muscle cell proliferation and differentiation. Cell Death Dis (2014) 5 : e1347

Tamoxifen ameliorates renal tubulointerstitial fibrosis by modulation of estrogen receptor -mediated transforming growth factor-1/Smad signaling pathway. Nephrol. Dial. Transplant. (2014) Nov 29 11: 2043-53

Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus. Oncotarget (2014) Jun 15 5 11: 3907-18

Melatonin reduced microglial activation and alleviated neuroinflammation induced neuron degeneration in experimental traumatic brain injury: Possible involvement of mTOR pathway. Neurochem. Int. (2014) Oct 76 : 23-31

Pretreatment with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxy--D-pyranoside attenuates cerebral ischemia/reperfusion-induced injury in vitro and in vivo. PLoS ONE (2014) 9 7: e100126

Mark4 promotes adipogenesis and triggers apoptosis in 3T3-L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways. Biol. Cell (2014) Sep 106 9: 294-307

An axis involving SNAI1, microRNA-128 and SP1 modulates glioma progression. PLoS ONE (2014) 9 6: e98651

Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma. Cancer Lett. (2014) Oct 1 352 2: 160-8

MiR-124 governs glioma growth and angiogenesis and enhances chemosensitivity by targeting R-Ras and N-Ras. Neuro-oncology (2014) Oct 16 10: 1341-53

Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. Biochem. Pharmacol. (2014) Aug 1 90 3: 265-75

FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells. Anticancer Drugs (2014) Sep 25 8: 898-907

Toll-like receptor 6 V327M polymorphism is associated with an increased risk of Klebsiella pneumoniae infection. Pediatr. Infect. Dis. J. (2014) Nov 33 11: e310-5

Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis. Clin. Exp. Immunol. (2014) Sep 177 3: 586-97

Smurf2 negatively modulates RIG-I-dependent antiviral response by targeting VISA/MAVS for ubiquitination and degradation. J. Immunol. (2014) May 15 192 10: 4758-64

Catalpol promotes oligodendrocyte survival and oligodendrocyte progenitor differentiation via the Akt signaling pathway in rats with chronic cerebral hypoperfusion. Brain Res. (2014) Apr 29 1560 : 27-35

Asiaticoside attenuates memory impairment induced by transient cerebral ischemia-reperfusion in mice through anti-inflammatory mechanism. Pharmacol. Biochem. Behav. (2014) Jul 122 : 15-Jul

Overexpression of BAT3 alleviates prion protein fragment PrP106-126-induced neuronal apoptosis. CNS Neurosci Ther (2014) Aug 20 8: 737-47

MiR-145, miR-133a and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer. FEBS Lett. (2014) Apr 2 588 7: 1168-77

Transcription factor Runx2 in the low bone mineral density of girls with adolescent idiopathic scoliosis. Orthop Surg (2014) Feb 6 1: 8-14

Quantitative proteomics approach to screening of potential diagnostic and therapeutic targets for laryngeal carcinoma. PLoS ONE (2014) 9 2: e90181

The Epstein-Barr virus-encoded microRNA MiR-BART9 promotes tumor metastasis by targeting E-cadherin in nasopharyngeal carcinoma. PLoS Pathog. (2014) Feb 10 2: e1003974

Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling. J. Virol. (2014) May 88 9: 5152-64

Interferon regulatory factor 8 protects against cerebral ischaemic-reperfusion injury. J. Neurochem. (2014) Jun 129 6: 988-1001

IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling. Nat Commun (2014) 5 : 3303

IRF4 is a novel mediator for neuronal survival in ischaemic stroke. Cell Death Differ. (2014) Jun 21 6: 888-903

Snail contributes to the maintenance of stem cell-like phenotype cells in human pancreatic cancer. PLoS ONE (2014) 9 1: e87409

An EGFR gene of the Pacific oyster Crassostrea gigas functions in wound healing and promotes cell proliferation. Mol. Biol. Rep. (2014) May 41 5: 2757-65

Progesterone signaling/miR-200a/zeb2 axis regulates self-renewal of mouse embryonic stem cells. Biomed. Pharmacother. (2014) Mar 68 2: 201-8

CRH suppressed TGF1-induced Epithelial-Mesenchymal Transition via induction of E-cadherin in breast cancer cells. Cell. Signal. (2014) Apr 26 4: 757-65

Effects of angiotensin II type 2 receptor overexpression on the growth of hepatocellular carcinoma cells in vitro and in vivo. PLoS ONE (2013) 8 12: e83754

GSTpi protects against angiotensin II-induced proliferation and migration of vascular smooth muscle cells by preventing signal transducer and activator of transcription 3 activation. Biochim. Biophys. Acta (2014) Feb 1843 2: 454-63

Concerted suppression of STAT3 and GSK3 is involved in growth inhibition of non-small cell lung cancer by Xanthatin. PLoS ONE (2013) 8 11: e81945

HSP27 phosphorylation modulates TRAIL-induced activation of Src-Akt/ERK signaling through interaction with -arrestin2. Cell. Signal. (2014) Mar 26 3: 594-602

Expression and cell distribution of receptor for advanced glycation end-products in the rat cortex following experimental subarachnoid hemorrhage. Brain Res. (2014) Jan 16 1543 : 315-23

Interferon regulatory factor 8 modulates phenotypic switching of smooth muscle cells by regulating the activity of myocardin. Mol. Cell. Biol. (2014) Feb 34 3: 400-14

Combined inhibition of epidermal growth factor receptor and cyclooxygenase-2 leads to greater anti-tumor activity of docetaxel in advanced prostate cancer. PLoS ONE (2013) 8 10: e76169

Disruption of tumor necrosis factor receptor associated factor 5 exacerbates pressure overload cardiac hypertrophy and fibrosis. J. Cell. Biochem. (2014) Feb 115 2: 349-58

NOD2 deletion promotes cardiac hypertrophy and fibrosis induced by pressure overload. Lab. Invest. (2013) Oct 93 10: 1128-36

Multifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation. Int. J. Cancer (2014) Apr 15 134 8: 1958-71

Puerarin attenuates pressure overload-induced cardiac hypertrophy. J Cardiol (2014) Jan 63 1: 73-81

The role of NADPH oxidase in taurine attenuation of Streptococcus uberis-induced mastitis in rats. Int. Immunopharmacol. (2013) Aug 16 4: 429-35

Serum amyloid A stimulates lipoprotein-associated phospholipase A2expression invitro and invivo. Atherosclerosis (2013) Jun 228 2: 370-9

The prostate cancer-up-regulated Myc-associated zinc-finger protein (MAZ) modulates proliferation and metastasis through reciprocal regulation of androgen receptor. Med. Oncol. (2013) 30 2: 570

miR-154 inhibits EMT by targeting HMGA2 in prostate cancer cells. Mol. Cell. Biochem. (2013) Jul 379 1-2: 69-75

A laboratory evaluation of medicinal herbs used in china for the treatment of hand, foot, and mouth disease. Evid Based Complement Alternat Med (2013) 2013 : 504563

Blockade of substance P receptor attenuates osteoporotic pain, but not bone loss, in ovariectomized mice. Menopause (2013) Oct 20 10: 1074-83

Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats. Psychopharmacology (Berl.) (2013) Aug 228 4: 585-94

Cathepsin K knockout alleviates pressure overload-induced cardiac hypertrophy. Hypertension (2013) Jun 61 6: 1184-92

IGF1 promotes osteogenic differentiation of mesenchymal stem cells derived from rat bone marrow by increasing TAZ expression. Biochem. Biophys. Res. Commun. (2013) Apr 5 433 2: 226-31

Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice. Hepatology (2013) Aug 58 2: 603-16

Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease. J Ethnopharmacol (2013) May 2 147 1: 114-21

Relationship of glucocorticoid receptor expression in peripheral blood mononuclear cells and the cochlea of guinea pigs and effects of dexamethasone administration. PLoS ONE (2013) 8 2: e56323

Fenofibrate down-regulates the expressions of androgen receptor (AR) and AR target genes and induces oxidative stress in the prostate cancer cell line LNCaP. Biochem. Biophys. Res. Commun. (2013) Mar 8 432 2: 320-5

In Vivo and In Vitro Antinociceptive Effect of Fagopyrum cymosum (Trev.) Meisn Extracts: A Possible Action by Recovering Intestinal Barrier Dysfunction. Evid Based Complement Alternat Med (2012) 2012 : 983801

Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis. Cell. Signal. (2013) May 25 5: 1176-85

Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen-glucose deprivation. Neurosci. Lett. (2013) Feb 22 535 : 51-6

Angiotensin II and angiotensin-(1-7) in paraventricular nucleus modulate cardiac sympathetic afferent reflex in renovascular hypertensive rats. PLoS ONE (2012) 7 12: e52557

Effects of the yangjing capsule extract on steroidogenesis and apoptosis in mouse leydig cells. Evid Based Complement Alternat Med (2012) 2012 : 985457

Baicalein protects against cardiac hypertrophy through blocking MEK-ERK1/2 signaling. J. Cell. Biochem. (2013) May 114 5: 1058-65

Angiotensin-(1-7) in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats. PLoS ONE (2012) 7 11: e48966

Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation. Antiviral Res. (2012) Jul 95 1: 30-6

Taurine attenuates lipopolysaccharide-induced disfunction in mouse mammary epithelial cells. Cytokine (2012) Jul 59 1: 35-40

The prostate cancer-up-regulated long noncoding RNA PlncRNA-1 modulates apoptosis and proliferation through reciprocal regulation of androgen receptor. Urol. Oncol. (2013) Oct 31 7: 1117-23

Houttuynia cordata blocks HSV infection through inhibition of NF-B activation. Antiviral Res. (2011) Nov 92 2: 341-5

Prevention of FGF-2-induced angiogenesis by scopoletin, a coumarin compound isolated from Erycibe obtusifolia Benth, and its mechanism of action. Int. Immunopharmacol. (2011) Dec 11 12: 2007-16

HSP75 protects against cardiac hypertrophy and fibrosis. J. Cell. Biochem. (2011) Jul 112 7: 1787-94

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Total Citations (229)
Description: Mouse monoclonal (1D4) antibody to GAPDH.
Application: WB, ICC/IF, IHC
Host: Mouse
Isotype: IgM
Reactivity: Human, Horse, Cow, Porcine, Chicken, Rat, Mouse

£198 – £763

Total Citations (117)
Description: Rabbit polyclonal antibody to GAPDH
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat Mammals
Immunogen: Recombinant full length Human GAPDH.

£157 – £269

start icons start icons start icons start icons start icons (2)
Total Citations (34)
Description: Goat polyclonal antibody to GAPDH.
Application: ELISA, WB, IF, IHC
Host: Goat
Isotype: IgG
Reactivity: Human, Mouse, Rat

£205

Total Citations (24)
Description: Rabbit polyclonal antibody to GAPDH (A531)
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat Mammals
Immunogen: Recombinant full length Human GAPDH.

£157 – £269

Please Note: Anti-GAPDH (1A6) Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
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